Invitrogen™ PZP Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5110249

Catalog No. PIPA5110249

Description

Immunogen sequence: VKDLTNFPDN VDQQEEEQGH CPRPFFIHNG AIYVPLSSNE ADIYSFLKGM GLKVFTNSKI RKPKSCSVIP SVSAGAVGQG YYGAGLGVVE RPYVPQLGTY NVIPLNNEQS SGPVPETVRS Y.

The protein encoded by this gene is highly expressed in late-pregnancy serum and is similar in structure to alpha-2-macroglobulin. The encoded protein, which acts as a homotetramer, inhibits the activity of all four classes of proteinases. This protein contains cleavage sites for several proteinases. Upon binding of a proteinase, the conformation of this protein changes to trap the proteinase, limiting its activity. This protein appears to be elevated in the sera of presymptomatic Alzheimer's disease patients.

Specifications

• Antigen: PZP
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PZP
• Gene Alias: A1m; A1m {ECO:0000312; A2m; AI893533; alpha 1 macroglobulin; alpha-1-M; Alpha-1-macroglobulin; alpha-1-macroglobulin 165 kDa subunit; Alpha-1-macroglobulin 45 kDa subunit; alpha-2-M; alpha-2-macroglobulin; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6; CPAMD6; EMBL:AAA40723.1}; MAM; Pregnancy zone protein; pregnancy-zone protein; Pzp; PZP, alpha-2-macroglobulin like
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 11287, 252922, 5858
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.92 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: P20742, Q61838, Q63041
• Gene Symbols: PZP
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 620-740 of human PZP (NP_002855.2).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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