Invitrogen™ QKI Monoclonal Antibody (GT1589)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA527804

Catalog No. PIMA527804

Description

Positive Control: 293T Predicted Reactivity: Xenopus laevis (93%), Dog (100%), Cat (100%), Pig (100%), Chicken (98%), Bovine (100%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

This gene encodes the sacsin protein, which includes a UbL domain at the N-terminus, a DnaJ domain, and a HEPN domain at the C-terminus. The gene is highly expressed in the central nervous system, also found in skin, skeletal muscles and at low levels in the pancreas. This gene includes a very large exon spanning more than 12.8 kb. Mutations in this gene result in autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS), a neurodegenerative disorder characterized by early-onset cerebellar ataxia with spasticity and peripheral neuropathy. Sacsin has been found to protect against mutant ataxin-1. A pseudogene associated with this gene is located on chromosome 11. Alternative splicing of this gene results in multiple transcript variants.

Specifications

• Antigen: QKI
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with no preservative
• Gene Accession No.: Q91XU1, Q96PU8, Q9QYS9
• Gene Symbols: Qk, QKI
• Immunogen: Recombinant protein encompassing a sequence within the center region of human QKI. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Clone: GT1589
• Conjugate: Unconjugated
• Gene: QKI
• Gene Alias: 1110003F05Rik; 1500005P18; DKFZp586I0923; HKQ; homolog of mouse quaking QKI (KH domain RNA binding protein); Hqk; hqkI; l(17)-1Wis; l17Wis1; lethal, Chr 17, U Wisconsin 1; MqkI; Protein quaking; protein quaking-like; Qk; QK1; QK3; Qka1; Qki; QKI, KH domain containing RNA binding; QKI, KH domain containing, RNA binding; QKI-5 protein; quaking; quaking homolog, KH domain RNA binding; RNA Binding (QKI); RNA binding protein HQK; rqkI
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 100910212, 19317, 499022, 9444
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid