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R&D Systems™ (R)-2-Hydroxyglutaric acid disodium salt, R&D Systems™
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Catalog No. 612450 Shop All Novus Biologicals Products
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61-245-0 50 mg
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Catalog No. 61-245-0 Supplier R&D Systems™ Supplier No. 6124/50

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Description

A Tocris product, part of R&D Systems. KDM4A inhibitor; also NF-κB activator

(R)-2-Hydroxyglutaric acid disodium salt is an oncometabolite produced by mutant isocitrate dehydrogenase 1 (IDH1) and IDH2. Inhibits KDM4A in murine embryonic fibroblasts resulting in activation of mTOR. Also activates NF-κB in bone marrow stromal cells and inhibits FTO (mRNA N6-methyladenine demethylase).

Specifications

Chemical Name or Material (R)-2-Hydroxyglutaric acid disodium salt
CAS 103404-90-6
Synonym (R)-2-Hydroxypentanedioic acid disodium salt
Quantity 50 mg
Solubility Soluble to 100mM in water
Product Line Tocris
Molecular Formula C5H6Na2O5
Formula Weight 192.08
Physical Form Solid
Color White
Product Type Bioactive Small Molecule
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