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  5. Tocris Bioscience™ (R)-CR8

Tocris Bioscience™ (R)-CR8
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Catalog No. 360510R
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Quantity:
10 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Cdk inhibitor; potently inhibits cdk1 and cdk2; also inhibits CK1; acts as molecular glue

(R)-CR8 is a cyclin dependent kinase (cdk) inhibitor (reported IC50 values are 0.036 - 0.07, 0.09 - 0.8, 0.13 - 0.68, 0.18 - 1 and >1 μM for cdk2, cdk1, cdk5, cdk9 and cdk7, respectively). Also inhibits casein kinase 1 (CK1; IC50 = 0.6 μM). Acts as molecular glue; forms a complex between CDK12-cyclin K and the CUL4 adapter protein DDB1 resulting in ubiquination and degradation of cyclin K.

Specifications

CAS 1786438-30-9
Quantity 10 mg
Molecular Formula C24H29N7O0.3 HCl
Product Type (2R)-2-[[9-(Methylethyl)-6-[[[4-(2-pyridinyl)phenyl]methyl]amino]-9H-purin-2-yl]amino]-1-butanol trihydrochloride
Purity 99%
Molecular Weight (g/mol) M.W. (Observed): 540.92
Inhibitors (R)-CR8

For Research Use Only

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