R&D Systems AM 6545, Tocris™

High affinity and selective CB1 antagonist

Manufacturer: R&D Systems 5443/50

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Catalog No. 544350

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Research Use Only. Not For Human or Veterinary Use


    Chemical Name or Material AM 6545
    CAS 1245626-05-4
    Assay Percent Range >98%
    Molecular Formula C26H23Cl2N5O3S
    Formula Weight 556.46
    Synonym 5-[4-(4-Cyano-1-butyn-1-yl)phenyl]-1-(2,4-dichlorophenyl)-N-(1,1-dioxido-4-thiomorpholinyl)-4-methyl-1H-pyrazole-3-carboxamide
    Recommended Storage Store at +4°C.
    Quantity 50mg
    Solubility Soluble to 20mM in DMSO
    Physical Form Solid
    Product Type Bioactive Small Molecules

    • Exhibits >100-fold selectivity for CB1 over CB2 receptors
    • Improves glucose homeostasis, reverses hepatic steatosis and reduces body weight in diet-induced obese mice
    • Orally available and non-brain penetrant

  • Description & Specifications

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