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Tocris Bioscience™ C16
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Catalog No. 538250
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Catalog No. 538250 Supplier Tocris Bioscience™ Supplier No. 5382/50
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Description

PKR inhibitor

C16 is a PKR inhibitor (IC50 = 210 nM). Rescues PKR-dependent translation block in vitro. Decreases Aβ42-induced inflammatory cytokine release and apoptosis in neuronal cultures. Prevents neuroinflammation and neuronal loss in an acute excitotoxic rat model. Brain penetrant.

Specifications

Chemical Name or Material C16
CAS 608512-97-6
Synonym 6,8-Dihydro-8-(1H-imidazol-5-ylmethylene)-7H-pyrrolo[2,3-g]benzothiazol-7-one
Quantity 50 mg
Solubility Soluble to 50mM in DMSO and to 20mM in ethanol
Molecular Formula C13H8N4OS
Formula Weight 268.29
Physical Form Solid
Product Type Bioactive Small Molecule
Purity >98%

Research Use Only. Not For Human or Veterinary Use

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