Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Protein Analysis Reagents
  4. Bioactive Small Molecules
  5. 55201

R&D Systems™ Echinomycin
GREENER_CHOICESDP

Catalog No. 55201 Shop All Novus Products
Change view
Click to view available options
Quantity:
1 mg
1 product options available for selection
Product selection table with 1 available options. Use arrow keys to navigate and Enter or Space to select.
Catalog No. Quantity
55201 1 mg
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 1 options available.
1 options
This item is not returnable. View return policy
Catalog No. 55201 Supplier R&D Systems™ Supplier No. 5520/1

Customers require a valid business account associated to their profile to access pricing and ordering options.

missing translation for 'validMainframeMsg'

This item is not returnable. View return policy

Description

A Tocris product, part of R&D Systems. Highly potent and selective HIF-1α inhibitor

Echinomycin is a highly potent and selective HIF-1α inhibitor (IC50 = 29.4 pM). Selectively inhibits HIF-1 binding to the VEGF promoter without affecting the binding of AP-1 or NF-κB. Inhibits colony formation of cancer stem cells (CSC) with a 100-fold selectivity over normal hematopoietic progenitor cells. Eradicates mouse lymphomas and human AML xenografts by eliminating CSCs.

Specifications

Chemical Name or Material Echinomycin
CAS 512-64-1
Synonym N-(2-Quinoxalinylcarbonyl)-O-[N-(2-quinoxalinylcarbonyl)-D-seryl-L-alanyl-3-mercapto-N,S-dimethylcysteinyl-N-methyl-L-valyl]-D-seryl-L-alanyl-N-methylcysteinyl-N-methyl-L-valine-(81)-lactone-cyclic (37)-thioether
Quantity 1 mg
Solubility Soluble to 5mM in DMSO
Product Line Tocris
Molecular Formula C51H64N12O12S2
Formula Weight 1101.26
Physical Form Solid
Product Type Bioactive Small Molecule
Purity >98%
Show More Show Less

Research Use Only. Not For Human or Veterinary Use

Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.