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Tocris Bioscience™ Echinomycin
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Catalog No. 55201
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Quantity:
1 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Highly potent and selective HIF-1α inhibitor

Echinomycin is a highly potent and selective HIF-1α inhibitor (IC50 = 29.4 pM). Selectively inhibits HIF-1 binding to the VEGF promoter without affecting the binding of AP-1 or NF-κB. Inhibits colony formation of cancer stem cells (CSC) with a 100-fold selectivity over normal hematopoietic progenitor cells. Eradicates mouse lymphomas and human AML xenografts by eliminating CSCs.

Specifications

Chemical Name or Material Echinomycin
CAS 512-64-1
Synonym N-(2-Quinoxalinylcarbonyl)-O-[N-(2-quinoxalinylcarbonyl)-D-seryl-L-alanyl-3-mercapto-N,S-dimethylcysteinyl-N-methyl-L-valyl]-D-seryl-L-alanyl-N-methylcysteinyl-N-methyl-L-valine-(81)-lactone-cyclic (37)-thioether
Quantity 1 mg
Solubility Soluble to 5mM in DMSO
Molecular Formula C51H64N12O12S2
Formula Weight 1101.26
Physical Form Solid
Product Type Bioactive Small Molecule
Purity >98%

Research Use Only. Not For Human or Veterinary Use

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