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R&D Systems JTE 607 Dihydrochloride, Tocris™

Cytokine release inhibitor

Manufacturer:  R&D Systems 5185/10

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Catalog No. 518510

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Research Use Only. Not For Human or Veterinary Use



  • Inhibits production of IL-1β, IL-8, IL-6, IL-10 and TNFα (IC50 values are 5.9, 7.3, 8.8, 9.1 and 11.0nM, respectively) from LPS-stimulated PBMCs
  • Reduces proinflammatory cytokine-release and attenuates lung permeability in a rat lung injury model
  • Induces apoptosis in leukemia cells in vitro and prolongs survival in a mouse leukemia model
Description & Specifications


JTE 607 dihydrochloride
N-[3,5-Dichloro-2-hydroxy-4-[2-(4-methyl-1-piperazinyl)ethoxy]benzoyl]-L-phenylalanine ethyl ester dihydrochloride
Soluble to 100mM in water and to 100mM in DMSO
Bioactive Small Molecules

Safety and Handling

Recommended Storage : Desiccate at room temperature.

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