R&D Systems JTE 607 Dihydrochloride, Tocris
Cytokine release inhibitor
Manufacturer: R&D Systems 5185/10
- Inhibits production of IL-1β, IL-8, IL-6, IL-10 and TNFα (IC50 values are 5.9, 7.3, 8.8, 9.1 and 11.0nM, respectively) from LPS-stimulated PBMCs
- Reduces proinflammatory cytokine-release and attenuates lung permeability in a rat lung injury model
- Induces apoptosis in leukemia cells in vitro and prolongs survival in a mouse leukemia model
|JTE 607 dihydrochloride|
|N-[3,5-Dichloro-2-hydroxy-4-[2-(4-methyl-1-piperazinyl)ethoxy]benzoyl]-L-phenylalanine ethyl ester dihydrochloride|
|Soluble to 100mM in water and to 100mM in DMSO|
|Bioactive Small Molecules|
Safety and Handling
Recommended Storage : Desiccate at room temperature.
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