R&D Systems JTE 607 Dihydrochloride, Tocris™

Cytokine release inhibitor

Manufacturer: R&D Systems 5185/10

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Catalog No. 518510

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Research Use Only. Not For Human or Veterinary Use


    Physical Form Solid,Solid
    Product Type Bioactive Small Molecules
    CAS 188791-09-5
    Assay Percent Range >98%
    Synonym N-[3,5-Dichloro-2-hydroxy-4-[2-(4-methyl-1-piperazinyl)ethoxy]benzoyl]-L-phenylalanine ethyl ester dihydrochloride
    Solubility Soluble to 100mM in water and to 100mM in DMSO
    Chemical Name or Material JTE 607 dihydrochloride
    Molecular Formula C25H31Cl2N3O5·2HCl
    Formula Weight 597.36
    Recommended Storage Desiccate at room temperature.
    Quantity 10mg

    • Inhibits production of IL-1β, IL-8, IL-6, IL-10 and TNFα (IC50 values are 5.9, 7.3, 8.8, 9.1 and 11.0nM, respectively) from LPS-stimulated PBMCs
    • Reduces proinflammatory cytokine-release and attenuates lung permeability in a rat lung injury model
    • Induces apoptosis in leukemia cells in vitro and prolongs survival in a mouse leukemia model

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