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Tocris Bioscience™ NS 8593 Hydrochloride
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Catalog No. 459750
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459750 50 mg
459710 10 mg
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Catalog No. 459750 Supplier Tocris Bioscience™ Supplier No. 4597/50
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Description

Selective negative modulator of KCa2 (SK) channels; inhibits SK currents

NS 8593 hydrochloride is a selective KCa2 (SK) channel negative modulator; inhibits SK channel currents (Kd values are 0.42, 0.6 and 0.73 μM for SK1, SK2 and SK3 respectively at 0.5 μM Ca2+). Exhibits selectivity for SK channels over KCa1.1 (BK), KCa3.1 (IK), Kv, Nav and Cav channels. Inhibits afterhyperpolarization in hippocampal slices.

Specifications

Chemical Name or Material NS 8593 hydrochloride
CAS 875755-24-1
Synonym N-[(1R)-1,2,3,4-Tetrahydro-1-naphthalenyl]-1H-benzimidazol-2-amine hydrochloride
Quantity 50 mg
Solubility Soluble to 100mM in DMSO and to 20mM in ethanol
Molecular Formula C17H17N3·HCl
Formula Weight 299.8
Physical Form Solid
Product Type Bioactive Small Molecule
Purity >98%

Research Use Only. Not For Human or Veterinary Use

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