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Tocris Bioscience™ NS 8593 Hydrochloride

Selective KCa2 (SK) channel negative modulator; inhibits SK currents

Manufacturer:  Tocris Bioscience™ 4597/50

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Catalog No. 459750


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Description

Description

Selective KCa2 (SK) channel negative modulator; inhibits SK channel currents (Kd values are 0.42, 0.6 and 0.73 μM for SK1, SK2 and SK3 respectively at 0.5 μM Ca2+). Exhibits selectivity for SK channels over KCa1.1 (BK), KCa3.1 (IK), Kv, Nav and Cav channels. Inhibits afterhyperpolarization in hippocampal slices.
Specifications

Specifications

NS 8593 hydrochloride
875755-24-1
299.8
50mg
Solid
>98%
C17H17N3·HCl
N-[(1R)-1,2,3,4-Tetrahydro-1-naphthalenyl]-1H-benzimidazol-2-amine hydrochloride
Soluble to 100mM in DMSO and to 20mM in ethanol
Bioactive Small Molecules
Safety and Handling

Safety and Handling

Recommended Storage : Store at +4°C.

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Research Use Only. Not For Human or Veterinary Use