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  5. Tocris Bioscience™ OICR 9429

Tocris Bioscience™ OICR 9429
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Catalog No. 526750
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Catalog No. 526750 Supplier Tocris Bioscience™ Supplier No. 5267/50
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Description

High affinity and selective WDR5 antagonist

OICR 9429 is a high affinity WDR5 antagonist (Kd = 93 nM; IC50 = 64 nM); disrupts WDR5-MLL interaction. Exhibits selectivity for WDR5 over 22 methyltransferases and a panel of kinases, GPCRs, ion channels, and transporters. Reduces viability of acute myeloid leukemia cells in vitro. Also disrupts MLL1-RbBP5 interaction.

To request the negative control for OICR 9429, please fill out the OICR 0547 request form on the SGC website.

Specifications

Chemical Name or Material OICR 9429
Synonym N-[2-(4-Methylpiperazin-1-yl)-5-[3-(morpholin-4-ylmethyl)phenyl]phenyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridine-3-carboxamide
Quantity 50 mg
Solubility Soluble to 50mM in DMSO
Target Additional Lysine Methyltransferase Compounds
Molecular Formula C29H32F3N5O3
Formula Weight 555.59
Physical Form Solid
Product Type Bioactive Small Molecule
Purity >98%

Research Use Only. Not For Human or Veterinary Use

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