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  5. Tocris Bioscience™ PFK 15

Tocris Bioscience™ PFK 15
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Catalog No. 533910
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Selective PFKFB3 inhibitor

PFK 15 is an originally reported to be a selective PFKFB3 inhibitor (IC50 = 207 nM); a more recent report failed to demonstrate activity in a PFKFB3 kinase assay. Selective for PFKFB3 over a panel of 96 kinases. Reduces glucose uptake and induces apoptosis in H522 lung adenocarcinoma and Jurkat T cell leukemia cells. Suppresses glucose uptake and tumor growth, and inhibits metastasis of Lewis lung carcinoma cell xenografts in mice.

Specifications

Chemical Name or Material PFK 15
CAS 4382-63-2
Synonym 1-(4-Pyridinyl)-3-(2-quinolinyl)-2-propen-1-one
Quantity 10 mg
Solubility Soluble to 100mM in DMSO
Molecular Formula C17H12N2O
Formula Weight 260.29
Physical Form Solid
Product Type Bioactive Small Molecule
Purity >99%

Research Use Only. Not For Human or Veterinary Use

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