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Tocris Bioscience™ TC-G 1008
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Catalog No. 535550
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Catalog No. 535550 Supplier Tocris Bioscience™ Supplier No. 5355/50
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Description

Potent and selective GPR39 agonist

Potent and selective GPR39 agonist (EC50 values are 0.4 and 0.8 nM for rat and human receptors respectively). Selective over a panel of kinases (IC50s > 10 μM) and displays minimal binding affinity for ghrelin and neurotensin-1 receptors (IC50s > 30 μM). Increases GLP-1 levels in vitro and in vivo. Reduces TNF-α-induced oxidative stress, mitochondrial dysfunction, cytokine expression and secretion of MMPs in fibroblast-like synoviocytes (FLS). Orally bioavailable.

TC-G 1008 is a potent and selective GPR39 agonist (EC50 values are 0.4 and 0.8 nM for rat and human receptors respectively). Selective over a panel of kinases (IC50s > 10 μM) and displays minimal binding affinity for ghrelin and neurotensin-1 receptors (IC50s > 30 μM). Increases GLP-1 levels in vitro and in vivo. Reduces TNF-α-induced oxidative stress, mitochondrial dysfunction, cytokine expression and secretion of MMPs in fibroblast-like synoviocytes (FLS). Orally bioavailable.

Specifications

Chemical Name or Material TC-G 1008
CAS 1621175-65-2
Synonym N-[3-Chloro-4-[[[2-(methylamino)-6-(2-pyridinyl)-4-pyrimidinyl]amino]methyl]phenyl]methanesulfonate
Quantity 50 mg
Solubility Soluble to 20mM in DMSO
Molecular Formula C18H19ClN6O2S
Formula Weight 418.9
Physical Form Solid
Product Type Bioactive Small Molecule
Purity >98%

Research Use Only. Not For Human or Veterinary Use

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