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  5. Tocris Bioscience™ VU 0469650 Hydrochloride

Tocris Bioscience™ VU 0469650 Hydrochloride
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Catalog No. 537910
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537950 50 mg
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Description

Potent and selective negative allosteric modulator of mGlu1

VU 0469650 hydrochloride is a potent and selective negative allosteric modulator of mGlu1 (IC50 = 99 nM). Exhibits >100-fold selectivity for mGlu1 over mGlu2-8 and 68 other GPCRs, ion channels, kinases and transporters. Brain penetrant.

Specifications

Chemical Name or Material VU 0469650 hydrochloride
CAS 1443748-47-7
Synonym 3-[(3R)-3-Methyl-4-(tricyclo[3.3.1.13,7]dec-1-ylcarbonyl)-1-piperazinyl]-2-pyridinecarbonitrile hydrochloride
Quantity 10 mg
Solubility Soluble to 100mM in DMSO and to 50mM in ethanol
Molecular Formula C22H28N4O·HCl
Formula Weight 400.94
Physical Form Solid
Product Type Bioactive Small Molecule
Purity >98%

Research Use Only. Not For Human or Veterinary Use

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