R&D Systems Zosuquidar Trihydrochloride, Tocris™

High affinity P-glycoprotein (P-gp) inhibitor

Manufacturer: R&D Systems 5456/10

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Catalog No. 545610

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Research Use Only. Not For Human or Veterinary Use


    Physical Form Solid,Solid
    Chemical Name or Material Zosuquidar trihydrochloride
    Product Type Bioactive Small Molecules
    CAS 167465-36-3
    Assay Percent Range >98%
    Molecular Formula C32H31F2N3O2·3HCl
    Formula Weight 636.99
    Synonym (αR)-4-[(1aα,6α,10bα)-1,1-Difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]-α-[(5-quinolinyloxy)methyl]-1-piperazineethanol trihydrochloride
    Recommended Storage Store at -20°C.
    Quantity 10mg
    Solubility Soluble to 50mM in DMSO

    • Restores doxorubicin sensitivity in P-gp-expressing multidrug (MDR) resistant cancer cell lines
    • Also potentiates antitumor efficacy of taxol in a MDR human non-small cell lung carcinoma xenograft mouse

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