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  5. Tocris Bioscience™ (R)-DRF053 dihydrochloride

Tocris Bioscience™ (R)-DRF053 dihydrochloride
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Catalog No. 361050R
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50 mg
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Catalog No. Quantity
36-105-0R 50 mg
36-101-0R 10 mg
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Catalog No. 36-105-0R Supplier Tocris Bioscience™ Supplier No. 3610/50
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Description

Potent CK1 inhibitor; also inhibits cyclin-dependent kinases

(R)-DRF053 dihydrochloride is a potent casein kinase 1 (CK1) inhibitor (IC50 = 14 nM). Also an ATP-competitive cyclin-dependent kinase (cdk) inhibitor (IC50 values are 0.093 - 0.29, 0.21 and 0.82 μM for cdk2, cdk5 and cdk7, respectively). Shown to inhibit amyloid-β production in N2A-APP695 cells.

Specifications

Quantity 50 mg
Product Type (R)-DRF053 dihydrochloride
Purity >98%
Molecular Weight (g/mol) 490.43
Inhibitors (R)-DRF053 dihydrochloride

For Research Use Only

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