Tocris™ (R)-DRF053 dihydrochloride

Dual CK1/cdk inhibitor

Manufacturer: Tocris™ 3610/50

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Catalog No. 36-105-0R

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For Research Use Only


    Inhibitors (R)-DRF053 dihydrochloride
    Molecular Weight 490.43
    Quantity 50mg
    Product Type (R)-DRF053 dihydrochloride
    Purity >98

    Potent, ATP-competitive inhibitor of cyclin-dependent kinase (cdk) and casein kinase 1 (CK1) (IC50 values are 220, 80 and 14nM for cdk1/cyclin B, cdk5/p25 and CK1 respectively). Selective over GSK-3 αβ (IC50= 4.1µM). Also shown to inhibit amyloid-β production in N2A-APP695 cells.

    • Chemical Name: 2-[[9-(1-Methylethyl)-6-[[3-(2-pyridinyl)phenyl]amino]-9H-purin-2-yl]amino]-1-butanol dihydrochloride
    • Formula: C23H27N7O.2HCl
    • CAS Number: 1241675-76-2
    • Solubility: Soluble to 100mM in water and to 100mM in DMSO
    • Purity: >98

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