Tocris (R)-DRF053 dihydrochloride
Dual CK1/cdk inhibitor
Manufacturer: Tocris 3610/50
DescriptionPotent, ATP-competitive inhibitor of cyclin-dependent kinase (cdk) and casein kinase 1 (CK1) (IC50 values are 220, 80 and 14nM for cdk1/cyclin B, cdk5/p25 and CK1 respectively). Selective over GSK-3 αβ (IC50= 4.1µM). Also shown to inhibit amyloid-β production in N2A-APP695 cells.
- Chemical Name: 2-[[9-(1-Methylethyl)-6-[[3-(2-pyridinyl)phenyl]amino]-9H-purin-2-yl]amino]-1-butanol dihydrochloride
- Formula: C23H27N7O.2HCl
- CAS Number: 1241675-76-2
- Solubility: Soluble to 100mM in water and to 100mM in DMSO
- Purity: >98
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