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Tocris Bioscience™ RA 2
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Catalog No. 712910
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71-291-0 10 mg
71-295-0 50 mg
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Description

Potent negative modulator of KCa2.3 and KCa3.1 channels

RA 2 is a potent negative modulator of calcium-activated potassium channels KCa2.3 and KCa3.1 (IC50 values are 2 and 17 nM, respectively), which displays >55-fold selectively for KCa2 and KCa3.1 over other KCa, Kv and Kir channels. In ex vivo porcine coronary endothelium, RA 2 inhibits SKA 31 (Cat. No. 3670)-induced KCa2/KCa3.1 currents and TRAM 34 (Cat. No. 2946)-insensitive KCa2 currents. Reduces heart rate in mice in a KCa3.1-dependent manner.

Specifications

Chemical Name or Material 1,3-Phenylenebis(methylene)bis(3-fluoro-4-hydroxybenzoate)
CAS 1867107-62-7
Quantity 10 mg
Target Ca2+-Activated Potassium Channel Modulators
Molecular Formula C22H16F2O6
Purity 0.98
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