Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Protein Analysis Reagents
  4. Bioactive Small Molecules
  5. Tocris Bioscience™ RA 2

Tocris Bioscience™ RA 2
GREENER_CHOICE

Catalog No. 712950
Change view
Click to view available options
Quantity:
10 mg
50 mg
Catalog No. Quantity
71-295-0 50 mg
71-291-0 10 mg
2 options
This item is not returnable. View return policy

Catalog No. 71-295-0

Supplier: Tocris Bioscience™ 7129/50

Only null left
Add to Cart
Add to Cart
This item is not returnable. View return policy

Description

Potent negative modulator of KCa2.3 and KCa3.1 channels

RA 2 is a potent negative modulator of calcium-activated potassium channels KCa2.3 and KCa3.1 (IC50 values are 2 and 17 nM, respectively), which displays >55-fold selectively for KCa2 and KCa3.1 over other KCa, Kv and Kir channels. In ex vivo porcine coronary endothelium, RA 2 inhibits SKA 31 (Cat. No. 3670)-induced KCa2/KCa3.1 currents and TRAM 34 (Cat. No. 2946)-insensitive KCa2 currents. Reduces heart rate in mice in a KCa3.1-dependent manner.

Specifications

Chemical Name or Material 1,3-Phenylenebis(methylene)bis(3-fluoro-4-hydroxybenzoate)
CAS 1867107-62-7
Quantity 50 mg
Target Ca2+-Activated Potassium Channel Modulators
Molecular Formula C22H16F2O6
Purity 0.98
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.