Invitrogen™ RAB11A Monoclonal Antibody (7C10)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA124919

Catalog No. PIMA124919

Description

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Rab11A is a member of the YPT-1 subfamily of Ras-related GTP-binding proteins. Rab11A mRNA has been detected in a variety of tissues including brain, testis, spleen, heart, and gastrointestinal mucosa. In the gastric fundus the Rab11A protein is expressed in parietal cell tubulovesicles membranes. Expression of the Rab11A protein appears to occur in discrete epithelial cell populations where it localizes to apical vesicular populations. Recent studies have shown Rab11A is essential for resecretion of alpha-synuclein out of neuronal cells via endosome recycling and is required for exocytosis of discoidal/fusiform vesicles of bladder umbrella cells. Rab11A is also implicated in biogenesis of Birbeck granules and endosomal activation of the PI3K/AKT signaling pathway via G beta gamma trafficking.

Specifications

• Antigen: RAB11A
• Classification: Monoclonal
• Concentration: 1.1 mg/mL
• Formulation: PBS with no preservative
• Gene Accession No.: P62491
• Gene Symbols: RAB11A
• Immunogen: Synthetic peptide corresponding to residues K Q M S D R R E N D M of Rab11A (aa 179-190).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: ELISA, Western Blot
• Clone: 7C10
• Conjugate: Unconjugated
• Gene: RAB11A
• Gene Alias: 24KG; RAB 11A, member oncogene family; RAB11; rab-11; rab11 GTP-binding protein; Rab11a; RAB11a, member RAS oncogene family; ras-related protein Rab-11A; tubulovesicle-associated protein; YL8
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 8766
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid