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Invitrogen™ RAB11A Recombinant Rabbit Monoclonal Antibody (3H18L5), Alexa Fluor™ 488
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Catalog No. PIMA7184A48
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PIMA7184A48 50 μL
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Catalog No. PIMA7184A48 Supplier Invitrogen™ Supplier No. MA700184A488
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Description

Rabbit Recombinant Monoclonal Antibody

This antibody is predicted to react with bovine, chicken, equine, mouse, primate, rat, Xenopus and zebrafish based on sequence homology Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Rab11A is a member of the YPT-1 subfamily of Ras-related GTP-binding proteins. Rab11A mRNA has been detected in a variety of tissues including brain, testis, spleen, heart, and gastrointestinal mucosa. In the gastric fundus the Rab11A protein is expressed in parietal cell tubulovesicles membranes. Expression of the Rab11A protein appears to occur in discrete epithelial cell populations where it localizes to apical vesicular populations. Recent studies have shown Rab11A is essential for resecretion of alpha-synuclein out of neuronal cells via endosome recycling and is required for exocytosis of discoidal/fusiform vesicles of bladder umbrella cells. Rab11A is also implicated in biogenesis of Birbeck granules and endosomal activation of the PI3K/AKT signaling pathway via G beta gamma trafficking.
TRUSTED_SUSTAINABILITY

Specifications

Antigen RAB11A
Applications Immunocytochemistry
Classification Recombinant Monoclonal
Clone 3H18L5
Concentration 1 mg/mL
Conjugate Alexa Fluor 488
Formulation PBS with 1mg/mL BSA and 0.05% sodium azide; pH 7.4
Gene RAB11A
Gene Accession No. P62491
Gene Alias 24KG; RAB 11A, member oncogene family; RAB11; rab-11; rab11 GTP-binding protein; Rab11a; RAB11a, member RAS oncogene family; ras-related protein Rab-11A; tubulovesicle-associated protein; YL8
Gene Symbols RAB11A
Host Species Rabbit
Immunogen A peptide corresponding to amino acids 179-194 of human Rab11.
Purification Method Protein A
Quantity 50 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 8766
Target Species Human
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Isotype IgG
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