Invitrogen™ RAB21 Monoclonal Antibody (OTI6E12)

Catalog No.	Quantity
PIMA526200	100 μL

Catalog No. PIMA526200 Supplier Invitrogen™ Supplier No. MA526200

Description

Mouse Monoclonal Antibody

RAB21 Monoclonal Antibody for ICC/IF, IHC (P), Western Blot

RAB21 is a member of a subfamily of small GTP-binding protein genes of the Ras superfamily that plays an important role in intracellular vesicular targeting. In non-polarized Caco-2 cells, RAB21 showed a general endoplasmic reticulum (ER)-like localization, while in polarized cells, RAB21 localized to apical vesicles. RAB21 has been shown to associate with integrin subunits and to be important for receptor entry into cells via RAB5/RAB21 endosomes. The GTPase-activating protein p120RasGAP regulates cell motility by controlling the return of the endocytosed integrins to the plasma membrane by competing with RAB21 for binding to overlapping sites on the Alpha-tail of endocytosed integrin.

Specifications

• Antigen: RAB21
• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Classification: Monoclonal
• Clone: OTI6E12
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: RAB21
• Gene Accession No.: P35282, P55745, Q6AXT5, Q9UL25
• Gene Alias: 9630024B22; GTP-binding protein RAB21; KIAA0118; Rab-12; Rab21; RAB21, member RAS oncogene family; ras-related protein Rab-21
• Gene Symbols: RAB21
• Host Species: Mouse
• Immunogen: Full length human recombinant protein of RAB21 produced in HEK293T cell.
• Purification Method: Protein A/G
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 100683312, 216344, 23011, 299799
• Target Species: Human, Mouse, Rat, Canine, Monkey
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG2b