Invitrogen™ RAB21 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA534404

Catalog No. PIPA534404

Description

A suggested positive control is mouse kidney tissue lysate. PA5-34404 can be used with blocking peptide PEP-1446.

RAB21 is a member of a subfamily of small GTP-binding protein genes of the Ras superfamily that plays an important role in intracellular vesicular targeting. In non-polarized Caco-2 cells, RAB21 showed a general endoplasmic reticulum (ER)-like localization, while in polarized cells, RAB21 localized to apical vesicles. RAB21 has been shown to associate with integrin subunits and to be important for receptor entry into cells via RAB5/RAB21 endosomes. The GTPase-activating protein p120RasGAP regulates cell motility by controlling the return of the endocytosed integrins to the plasma membrane by competing with RAB21 for binding to overlapping sites on the Alpha-tail of endocytosed integrin.

Specifications

• Antigen: RAB21
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RAB21
• Gene Alias: 9630024B22; GTP-binding protein RAB21; KIAA0118; Rab-12; Rab21; RAB21, member RAS oncogene family; ras-related protein Rab-21
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 216344, 23011, 299799
• Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Immunohistochemistry, Western Blot
• Concentration: 1.5 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: P35282, Q6AXT5, Q9UL25
• Gene Symbols: RAB21
• Immunogen: A 19 amino acid synthetic peptide near the carboxy terminus of human RAB21.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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