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Invitrogen™ RAB21 Polyclonal Antibody
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Catalog No. PIPA588344
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100 μL
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PIPA588344 100 μL
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Catalog No. PIPA588344 Supplier Invitrogen™ Supplier No. PA588344
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: MAAAGGGGGG AAAAGRAYSF KVVLLGEGCV GKTSLVLRYC ENKFNDKHIT TLQASFLTKK LNIGGKRVNL AIWDTAGQER FHALGPIYYR DSNGAILVYD ITDEDSFQKV KNWVKELRKM LGNEICLCIV GNKIDLEKER HVSIQEAESY AESVGAKHYH TSAKQNKGIE ELFLDLCKRM IETAQVDERA KGNGSSQPGT ARRGVQIIDD EPQAQTSGGG CCSSG; Positive Samples: HT-29, 293T, Mouse heart; Cellular Location: Cleavage furrow, Cytoplasmic vesicle membrane, Early endosome membrane, Endoplasmic reticulum membrane, Golgi apparatus, Golgi apparatus membrane, Lipid-anchor, trans-Golgi network.

RAB21 is a member of a subfamily of small GTP-binding protein genes of the Ras superfamily that plays an important role in intracellular vesicular targeting. In non-polarized Caco-2 cells, RAB21 showed a general endoplasmic reticulum (ER)-like localization, while in polarized cells, RAB21 localized to apical vesicles. RAB21 has been shown to associate with integrin subunits and to be important for receptor entry into cells via RAB5/RAB21 endosomes. The GTPase-activating protein p120RasGAP regulates cell motility by controlling the return of the endocytosed integrins to the plasma membrane by competing with RAB21 for binding to overlapping sites on the Alpha-tail of endocytosed integrin.
TRUSTED_SUSTAINABILITY

Specifications

Antigen RAB21
Applications ELISA, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1.22 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene RAB21
Gene Accession No. P35282, Q6AXT5, Q9UL25
Gene Alias 9630024B22; GTP-binding protein RAB21; KIAA0118; Rab-12; Rab21; RAB21, member RAS oncogene family; ras-related protein Rab-21
Gene Symbols RAB21
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-225 of human RAB21 (NP_0558141).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 216344, 23011, 299799
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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