Invitrogen™ RAB21 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA588344

Catalog No. PIPA588344

Description

Immunogen sequence: MAAAGGGGGG AAAAGRAYSF KVVLLGEGCV GKTSLVLRYC ENKFNDKHIT TLQASFLTKK LNIGGKRVNL AIWDTAGQER FHALGPIYYR DSNGAILVYD ITDEDSFQKV KNWVKELRKM LGNEICLCIV GNKIDLEKER HVSIQEAESY AESVGAKHYH TSAKQNKGIE ELFLDLCKRM IETAQVDERA KGNGSSQPGT ARRGVQIIDD EPQAQTSGGG CCSSG; Positive Samples: HT-29, 293T, Mouse heart; Cellular Location: Cleavage furrow, Cytoplasmic vesicle membrane, Early endosome membrane, Endoplasmic reticulum membrane, Golgi apparatus, Golgi apparatus membrane, Lipid-anchor, trans-Golgi network.

RAB21 is a member of a subfamily of small GTP-binding protein genes of the Ras superfamily that plays an important role in intracellular vesicular targeting. In non-polarized Caco-2 cells, RAB21 showed a general endoplasmic reticulum (ER)-like localization, while in polarized cells, RAB21 localized to apical vesicles. RAB21 has been shown to associate with integrin subunits and to be important for receptor entry into cells via RAB5/RAB21 endosomes. The GTPase-activating protein p120RasGAP regulates cell motility by controlling the return of the endocytosed integrins to the plasma membrane by competing with RAB21 for binding to overlapping sites on the Alpha-tail of endocytosed integrin.

Specifications

• Antigen: RAB21
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RAB21
• Gene Alias: 9630024B22; GTP-binding protein RAB21; KIAA0118; Rab-12; Rab21; RAB21, member RAS oncogene family; ras-related protein Rab-21
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 216344, 23011, 299799
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot, Immunocytochemistry
• Concentration: 1.22 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: P35282, Q6AXT5, Q9UL25
• Gene Symbols: RAB21
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-225 of human RAB21 (NP_0558141).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG