Invitrogen™ RAB23 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA556068

Catalog No. PIPA556068

Description

Immunogen sequence: EDLNVNEVFK YLAEKYLQKL KQQIAEDPEL THSSSNKIGV FNTSGGSHSG QNSGTLNGGD VINLRPNKQR TKK Highest antigen sequence identity to the following orthologs: Mouse - 85%, Rat - 86%.

The Ras-related superfamily of guanine nucleotide binding proteins includes the R-Ras, Rap, Ral/Rec and Rho/Rab subfamilies. Increasing data suggests an important role for Rab proteins in either endocytosis or in biosynthetic protein transport. The process of transporting newly synthesized proteins from the endoplasmic reticulum to various stacks of the Golgi complex and to secretory vesicles involves the movement of carrier vesicles and requires Rab protein function. Rab proteins are also an integral part of endocytic pathways. Rab 23, also known as HSPC137, is a 237 amino acid member of the Rab family of proteins and localizes to the cytoplasmic side of the cell membrane. Rab 23 is believed to play a role in intracellular protein transportation and signal transduction mediated by small GTPases. Mutations in the gene encoding Rab 23 may result in Carpenter syndrome, also known as ACPS2 (acrocephalopolysyndactyly type 2), a condition characterized by obesity, cardiac defects, polysyndactyly and craniosynostosis.

Specifications

• Antigen: RAB23
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RAB23
• Gene Alias: AW545388; DKFZp781H0695; HSPC137; MGC8900; opb; opb2; open brain 2; OTTHUMP00000040021; protein open brain; RAB 23; RAB family small GTP binding protein RAB 23; rab-15; RAB23; RAB23, member RAS oncogene family; ras-related protein Rab-23; RP3-496N17.3
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 51715
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.5 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9ULC3
• Gene Symbols: RAB23
• Immunogen: Recombinant protein corresponding to Human RAB23. Recombinant protein control fragment (Product #RP-94675).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG