Invitrogen™ RAB23 Polyclonal Antibody

Catalog No.	Quantity
PIPA596885	100 μL

Catalog No. PIPA596885 Supplier Invitrogen™ Supplier No. PA596885

Description

Rabbit Polyclonal Antibody

Immunogen sequence: MLEEDMEVAI KMVVVGNGAV GKSSMIQRYC KGIFTKDYKK TIGVDFLERQ IQVNDEDVRL MLWDTAGQEE FDAITKAYYR GAQACVLVFS TTDRESFEAV SSWREKVVAE VGDIPTVLVQ NKIDLLDDSC IKNEEAEALA KRLKLRFYRT SVKEDLNVNE VFKYLAEKYL QKLKQQIAED PELTHSSSNK IGVFNTSGGS HSGQNSGTLN GGDVINLRPN KQRTKKNRNP FSSCSIP; Positive Samples: HeLa, Mouse testis, Mouse brain, Mouse kidney, Mouse lung, Rat brain; Cellular Location: Cell membrane, Cytoplasm, Cytoplasmic side, Cytoplasmic vesicle, Endosome membrane, Lipid-anchor, autophagosome, phagosome, phagosome membrane.

The Ras-related superfamily of guanine nucleotide binding proteins includes the R-Ras, Rap, Ral/Rec and Rho/Rab subfamilies. Increasing data suggests an important role for Rab proteins in either endocytosis or in biosynthetic protein transport. The process of transporting newly synthesized proteins from the endoplasmic reticulum to various stacks of the Golgi complex and to secretory vesicles involves the movement of carrier vesicles and requires Rab protein function. Rab proteins are also an integral part of endocytic pathways. Rab 23, also known as HSPC137, is a 237 amino acid member of the Rab family of proteins and localizes to the cytoplasmic side of the cell membrane. Rab 23 is believed to play a role in intracellular protein transportation and signal transduction mediated by small GTPases. Mutations in the gene encoding Rab 23 may result in Carpenter syndrome, also known as ACPS2 (acrocephalopolysyndactyly type 2), a condition characterized by obesity, cardiac defects, polysyndactyly and craniosynostosis.

Specifications

• Antigen: RAB23
• Applications: ELISA, Western Blot
• Classification: Polyclonal
• Concentration: 0.82 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: RAB23
• Gene Accession No.: P35288, Q9ULC3
• Gene Alias: AW545388; DKFZp781H0695; HSPC137; MGC8900; opb; opb2; open brain 2; OTTHUMP00000040021; protein open brain; RAB 23; RAB family small GTP binding protein RAB 23; rab-15; RAB23; RAB23, member RAS oncogene family; ras-related protein Rab-23; RP3-496N17.3
• Gene Symbols: RAB23
• Host Species: Rabbit
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-237 of human RAB23 (NP_0573613).
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 19335, 367242, 51715
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG