Invitrogen™ RAB3GAP1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5120651

Catalog No. PIPA5120651

Description

Positive test controls include: HeLa, HepG2, Jurkat, Mouse lung, Mouse brain, Rat brain. Immunogen sequence: GLASGPPDLR CCLLHQKLQM LNCCIERKKA RDEGKKTSAS DVTNIYPGDA GKAGDQLVPD NLKETDKEKG EVGKSWDSWS DSEEEFFECL SDTEELKGNG QESGKKGGPK EMANLRPEGR LYQHGKLTLL HNGEPLYIPV TQEPAPMTED LLEEQSEVLA KLGTSAEGAH LRARMQSACL LSDMESFKAA NPGCSLEDFV RWYSPRDYIE EEVIDEKGNV VLKGELSARM KIPSNMWVEA WETAKPIPAR RQRRLFDDTR EAEKVLHYLA IQKPADLARH L.

RAB3GAP1, is a 981 amino acid protein that belongs to the Rab3-GAP catalytic subunit family. Rab 3 GAP p130 converts active RAB3-GTP to the inactive form RAB3-GDP, and is required for normal eye and brain development. Defects in Rab 3 GAP p130 are the cause of Warburg micro syndrome 1 (WARBM1). WARBM1 is a severe autosomal recessive disorder characterized by developmental abnormalities of the eye and central nervous system and by microgenitalia. The Rab 3 GAP p130 protein may participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters.

Specifications

• Antigen: RAB3GAP1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RAB3GAP1
• Gene Alias: 1700003B17Rik; 4732493F09Rik; AL117896; KIAA0066; P130; Rab 3 GAP p130; Rab3 GAP p130; RAB3 GTPase activating protein catalytic subunit 1; RAB3 GTPase activating protein subunit 1; RAB3 GTPase activating protein subunit 1 (catalytic); RAB3 GTPase-activating protein 130 kDa subunit; Rab3 GTPase-activating protein catalytic subunit; RAB3GAP; Rab3-GAP; Rab3-GAP p130; Rab3gap1; RAB3GAP130; RGD1306487; WARBM1
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 226407, 22930, 304759
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.8 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: P69735, Q15042, Q80UJ7
• Gene Symbols: RAB3GAP1
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 500-780 of human RAB3GAP1 (NP_001165906.1).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG