Invitrogen™ RAB43 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5104081

Catalog No. PIPA5104081

Description

Antibody detects endogenous levels of total RAB43.

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The low intrinsic GTPase activity of RAB43 is activated by USP6NL. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for the structural integrity of the Golgi complex. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis.

Specifications

• Antigen: RAB43
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RAB43
• Gene Alias: 1810048P08Rik; 2500004H21Rik; AW490415; RAB11B; RAB41; Rab43; RAB43, member RAS oncogene family; ras-related protein Rab-41; Ras-related protein Rab-43
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 339122, 69834
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q86YS6, Q8CG50
• Gene Symbols: RAB43
• Immunogen: A synthesized peptide derived from human RAB43(Accession Q86YS6), corresponding to amino acid residues E114-K164.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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