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Invitrogen™ RAB43 Polyclonal Antibody
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Catalog No. PIPA563813
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100 μL
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PIPA563813 100 μL
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Catalog No. PIPA563813 Supplier Invitrogen™ Supplier No. PA563813
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: EAFLRVATEL IMRHGGPLFS EKSPDHIQLN SKDIGEGW Highest antigen sequence identity to the following orthologs: Mouse - 82%, Rat - 82%.

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The low intrinsic GTPase activity of RAB43 is activated by USP6NL. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for the structural integrity of the Golgi complex. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen RAB43
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.4 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene RAB43
Gene Accession No. Q86YS6
Gene Alias 1810048P08Rik; 2500004H21Rik; AW490415; RAB11B; RAB41; Rab43; RAB43, member RAS oncogene family; ras-related protein Rab-41; Ras-related protein Rab-43
Gene Symbols RAB43
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human RAB43. Recombinant protein control fragment (Product #RP-103801).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 339122
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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