Invitrogen™ RAB7B Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5110262

Catalog No. PIPA5110262

Description

Sequence of this protein is as follows: MNPRKKVDLK LIIVGAIGVG KTSLLHQYVH KTFYEEYQTT LGASILSKII ILGDTTLKLQ IWDTGGQERF RSMVSTFYKG SDGCILAFDV TDLESFEALD IWRGDVLAKI VPMEQSYPMV LLGNKIDLAD RKVPQEVAQG WCREKDIPYF EVSAKNDINV VQAFEMLASR ALSRYQSILE NHLTESIKLS PDQSRSRCC.

Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway.

Specifications

• Antigen: RAB7B
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RAB7B
• Gene Alias: 5430435G22Rik; RAB7; Rab7b; RAB7B, member RAS oncogene family; Ras-related protein Rab-7; ras-related protein Rab-7b; RGD1562617; RIKEN cDNA 5430435G22 gene
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 226421, 338382
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot, Immunocytochemistry
• Concentration: 3.04 mg/mL
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
• Gene Accession No.: Q8VEA8, Q96AH8
• Gene Symbols: RAB7B
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-199 of human RAB7B (NP_001157994.1).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG