Invitrogen™ RAB8A Recombinant Rabbit Monoclonal Antibody (JE64-79)

Catalog No.	Quantity
PIMA549140	100 μL

Catalog No. PIMA549140 Supplier Invitrogen™ Supplier No. MA549140

Description

Rabbit Recombinant Monoclonal Antibody

Sequence Similarities: 100% Mouse/Rat Tissue Specificity: Low tissue specificity Positive Control: Hela cell lysate, HepG2 cell lysate, NIH/3T3 cell lysate, RAW264.7 cell lysate, C2C12 cell lysate, L6 cell lysate Subcellular location: Cell membrane, golgi apparatus, recycling endosome membrane, cytoplasm, centriole, cilium basal body, cilium axoneme, cilium, phagosome, phagosome membrane, midbody.

The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%, 96%, and 51% similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1.

Specifications

• Antigen: RAB8A
• Applications: Flow Cytometry, Immunoprecipitation, Western Blot, Immunocytochemistry
• Classification: Recombinant Monoclonal
• Clone: JE64-79
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: TBS with 0.05% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
• Gene: RAB8A
• Gene Accession No.: P35280, P55258, P61006
• Gene Alias: AA409338; cell line NK14 derived transforming oncogene; MEL; mel transforming oncogene (derived from cell line NK14); mel transforming oncogene (derived from cell line NK14)- RAB8 homolog; mel transforming oncogene (RAB8 homolog); oncogene c-mel; Rab8; Rab8a; RAB8A, member RAS oncogene family; ras-associated protein RAB8; ras-related protein Rab-8A
• Gene Symbols: RAB8A
• Host Species: Rabbit
• Immunogen: Synthetic peptide within human rab8a aa 151-200/207.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 117103, 17274, 4218
• Target Species: Human, Mouse, Rat
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov