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ABL1 Rabbit anti-Human, Mouse, Rat, Polyclonal Antibody, Abnova™

Catalog No. 89118780 Shop All Abnova Corporation Products
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89-118-780 100 μg
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Catalog No. 89-118-780 Supplier Abnova Corporation Supplier No. PAB16983
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Description

Rabbit polyclonal antibody raised against synthetic peptide of ABL1.

The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11. [provided by RefSeq

Specifications

Antigen ABL1
Applications ELISA, Immunohistochemistry (PFA fixed), Western Blot
Classification Polyclonal
Conjugate Unconjugated
Description Rabbit polyclonal antibody raised against synthetic peptide of ABL1.
Dilution Western Blot (1:500-1:1000) Immunohistochemistry (1:50-1:100) ELISA (1:20000) The optimal working dilution should be determined by the end user.
Formulation In 20mM PBS, 0.15M NaCl, pH 7.2 (0.01% sodium azide)
Gene ABL1
Gene Accession No. P00519
Gene Alias ABL/JTK7/bcr/abl/c-ABL/p150/v-abl
Gene Symbols ABL1
Host Species Rabbit
Immunogen A synthetic peptide corresponding to residues surrounding Y412 of human ABL1.
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 25
Test Specificity This antibody detects endogenous levels of total ABL1 protein.
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
Form Liquid
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