Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

MilliporeSigma™ Rabbit anti-acetyl-Histone H3, Alexa Fluor 647, Polyclonal

Rabbit Polyclonal Antibody

Manufacturer:  MilliporeSigma™ 06599AF647

Catalog No. 06-599-AF647

Add to cart



Specifically detects acetyl-Histone H3 in Human, Mouse samples, and it is validated for Immunocytochemistry

Histone H3 is one of the five main histone proteins that are involved in the structure of chromatin in eukaryotic cells. The chromatin fiber is composed on repetitive units, known as nucleosomes, which are comprised of an octamer of core histones (two each of H2A, H2B, H3, and H4), around which DNA are wrapped. Histone H3 features a main globular domain and a long N-terminal tail. The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several different types of epigenetic modifications that influence cellular processes. These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine. Histone H3 is specifically phosphorylated during both mitosis and meiosis in patterns that are specifically coordinated in space and time. These phosphorylations are initiated at different phases of the cell division. Histone H3 variants (H3.1, H3.2 and H3.3) have been implicated in the epigenetic memory of cellular state. Genome-wide patterns of H3 are dependent on amino acid sequence and change with cellular differentiation at developmentally regulated loci.


acetyl-Histone H3
Alexa Fluor 647
Synthetic peptide corresponding to human histone H3 N-terminal sequence with acetylated Lys9 and Lys14
Epigenetics and Nuclear Function
Purified rabbit antibody conjugate in buffer containing PBS, 15mg/mL BSA and 0.1% Sodium Azide.
Protein A Purfied
Stable for one year at 2°C to 8°C from date of receipt.
Human, Murine
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit

For Research Use Only