ACVR1 Rabbit anti-Human, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic peptide of ACVR1.

Supplier:  Abnova Corporation PAB2638

Catalog No. 89-128-020

Description

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. [provided by RefSeq

Specifications

• Antigen: ACVR1
• Classification: Polyclonal
• Description: Rabbit polyclonal antibody raised against synthetic peptide of ACVR1.
• Formulation: In PBS (0.09% sodium azide)
• Gene Accession No.: NP_001096;Q04771
• Gene Symbols: ACVR1
• Immunogen: A synthetic peptide (conjugated with KLH) corresponding to internal region of human ACVR1.
• Quantity: 400 μL
• Primary or Secondary: Primary
• Target Species: Human
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Conjugate: Unconjugated
• Dilution: Western Blot (1:1000) Immunohistochemistry (1:50-100) The optimal working dilution should be determined by the end user.
• Gene: ACVR1
• Gene Alias: ACTRI/ACVR1A/ACVRLK2/ALK2/FOP/SKR1/TSRI
• Host Species: Rabbit
• Purification Method: Ammonium sulfate precipitation
• Regulatory Status: RUO
• Gene ID (Entrez): 90
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.

For Research Use Only