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ACVR1 Rabbit anti-Human, Mouse, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic peptide of ACVR1.

Supplier:  Abnova Corporation PAB3474

Catalog No. 89-131-034


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Description

Description

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. [provided by RefSeq

Specifications

Specifications

ACVR1
Polyclonal
Rabbit polyclonal antibody raised against synthetic peptide of ACVR1.
In PBS (0.09% sodium azide)
NP_001096;Q04771
ACVR1
A synthetic peptide (conjugated with KLH) corresponding to internal region of human ACVR1.
400 μL
Primary
Human, Mouse
Liquid
ELISA, Immunohistochemistry (Paraffin), Western Blot
Unconjugated
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50-100) Western Blot (1:1000) The optimal working dilution should be determined by the end user.
ACVR1
ACTRI/ACVR1A/ACVRLK2/ALK2/FOP/SKR1/TSRI
Rabbit
Protein G purification
RUO
90
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
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