ACVR1B Rabbit anti-Human, Mouse, Polyclonal Antibody, Abnova™

Catalog No.	Quantity
89-131-028	400 μL

Catalog No. 89-131-028 Supplier Abnova Corporation Supplier No. PAB3465

Description

Rabbit polyclonal antibody raised against synthetic peptide of ACVR1B.

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with a cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type IB receptor, composed of 11 exons. Alternative splicing and alternative polyadenylation result in 3 fully described transcript variants. The mRNA expression of variants 1, 2, and 3 is confirmed, and a potential fourth variant contains an alternative exon 8 and lacks exons 9 through 11, but its mRNA expression has not been confirmed. [provided by RefSeq

Specifications

• Antigen: ACVR1B
• Applications: ELISA, Flow Cytometry, Western Blot
• Classification: Polyclonal
• Conjugate: Unconjugated
• Description: Rabbit polyclonal antibody raised against synthetic peptide of ACVR1B.
• Dilution: Flow Cytometry (1:10-50) Western Blot (1:1000) The optimal working dilution should be determined by the end user.
• Formulation: In PBS (0.09% sodium azide)
• Gene: ACVR1B
• Gene Accession No.: P36896
• Gene Alias: ACTRIB/ACVRLK4/ALK4/SKR2
• Gene Symbols: ACVR1B
• Host Species: Rabbit
• Immunogen: A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human ACVR1B.
• Purification Method: Ammonium sulfate precipitation
• Quantity: 400 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 91
• Target Species: Human, Mouse
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid

For Research Use Only