ACVR1B Rabbit anti-Human, Mouse, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic peptide of ACVR1B.

Supplier:  Abnova Corporation PAB3467

Catalog No. 89-131-029

Description

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with a cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type IB receptor, composed of 11 exons. Alternative splicing and alternative polyadenylation result in 3 fully described transcript variants. The mRNA expression of variants 1, 2, and 3 is confirmed, and a potential fourth variant contains an alternative exon 8 and lacks exons 9 through 11, but its mRNA expression has not been confirmed. [provided by RefSeq

Specifications

• Antigen: ACVR1B
• Classification: Polyclonal
• Description: Rabbit polyclonal antibody raised against synthetic peptide of ACVR1B.
• Formulation: In PBS (0.09% sodium azide)
• Gene Accession No.: P36896
• Gene Symbols: ACVR1B
• Immunogen: A synthetic peptide (conjugated with KLH) corresponding to internal region of human ACVR1B.
• Quantity: 400 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Form: Liquid

• Applications: ELISA, Flow Cytometry, Western Blot
• Conjugate: Unconjugated
• Dilution: Flow Cytometry (1:10-50) Western Blot (1:1000) The optimal working dilution should be determined by the end user.
• Gene: ACVR1B
• Gene Alias: ACTRIB/ACVRLK4/ALK4/SKR2
• Host Species: Rabbit
• Purification Method: Protein G purification
• Regulatory Status: RUO
• Gene ID (Entrez): 91
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.

For Research Use Only