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Description
This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2. [provided by RefSeq
Specifications
Specifications
| Antigen | ACVRL1 |
| Applications | ELISA, Immunohistochemistry (PFA fixed), Western Blot |
| Classification | Polyclonal |
| Conjugate | Unconjugated |
| Description | Rabbit polyclonal antibody raised against synthetic peptide of ACVRL1. |
| Dilution | ELISA (1:1000-1:10000) Western Blot (1:200-5000) Immunohistochemistry (1:100-300) The optimal working dilution should be determined by the end user. |
| Formulation | In serum (2% BSA, 0.02% sodium azide) |
| Gene | ACVRL1 |
| Gene Accession No. | NM_000020 |
| Gene Alias | ACVRLK1/ALK-1/ALK1/HHT/HHT2/ORW2/SKR3/TSR-I |
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