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Description
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene excises the N-propeptide of type I, type II and type V procollagens. Mutations in this gene cause Ehlers-Danlos syndrome type VIIC, a recessively inherited connective-tissue disorder. Alternative splicing results in two transcript variants. The short transcript encodes a protein which has no significant procollagen N-peptidase activity. [provided by RefSeq
Specifications
Specifications
| Antigen | ADAMTS2 |
| Applications | ELISA, Immunohistochemistry (PFA fixed), Western Blot |
| Classification | Polyclonal |
| Conjugate | Unconjugated |
| Description | Rabbit polyclonal antibody raised against synthetic peptide of ADAMTS2. |
| Dilution | ELISA (1:1000-1:10000) Western Blot (1:200-1:1000) Immunohistochemistry (1:100-1:500) The optimal working dilution should be determined by the end user. |
| Formulation | In buffer containing 0.02% sodium azide, 0.5% BSA |
| Gene | ADAMTS2 |
| Gene Alias | ADAM-TS2/ADAMTS-3/NPI/PCINP/PCPNI/hPCPNI |
| Gene Symbols | ADAMTS2 |
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