ADRA2B, Rabbit, Polyclonal Antibody, Abnova™

Catalog No.	Quantity
89-119-010	100 μg

Catalog No. 89-119-010 Supplier Abnova Corporation Supplier No. PAB17354

Description

Rabbit polyclonal antibody raised against synthetic peptide of ADRA2B.

Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. This gene encodes the alpha2B subtype, which was observed to associate with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. A polymorphic variant of the alpha2B subtype, which lacks 3 glutamic acids from a glutamic acid repeat element, was identified to have decreased G protein-coupled receptor kinase-mediated phosphorylation and desensitization; this polymorphic form is also associated with reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity. This gene contains no introns in either its coding or untranslated sequences. [provided by RefSeq

Specifications

• Antigen: ADRA2B
• Applications: Immunofluorescence
• Classification: Polyclonal
• Conjugate: Unconjugated
• Description: Rabbit polyclonal antibody raised against synthetic peptide of ADRA2B.
• Dilution: IImmunofluorescence (1:500-1:1000) ELISA (1:20000) The optimal working dilution should be determined by the end user.
• Formulation: In PBS, pH 7.4 (150mM NaCl, 0.02% sodium azide, 50% glycerol)
• Gene: ADRA2B
• Gene Accession No.: P18089
• Gene Alias: ADRA2L1/ADRA2RL1/ADRARL1/ALPHA2BAR
• Gene Symbols: ADRA2B
• Host Species: Rabbit
• Immunogen: A synthetic peptide corresponding to internal of human ADRA2B.
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 151
• Test Specificity: This antibody detects endogenous levels of total ADRA2B protein.
• Target Species: Human
• Content And Storage: Store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid

For Research Use Only