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AGTR2 Rabbit anti-Bovine, Dog, Hamster, Horse, Human, Monkey, Mouse, Pig, Rat, Sheep, Polyclonal Antibody, Abnova™

Catalog No. 89127166 Shop All Abnova Corporation Products
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89-127-166 50 μg
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Catalog No. 89-127-166 Supplier Abnova Corporation Supplier No. PAB25552
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Description

Rabbit polyclonal antibody raised against synthetic peptide of AGTR2.

Angiotensin II is a potent pressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors termed AT1 and AT2. AGTR2 belongs to a family 1 of G-protein coupled receptors. It is an integral membrane protein. It plays a role in the central nervous system and cardiovascular functions that are mediated by the renin-angiotensin system. This receptor mediates programmed cell death (apoptosis). In adults, it is highly expressed in myometrium with lower levels in adrenal gland and fallopian tube. It is highly expressed in fetal kidney and intestine. The human AGTR2 gene is composed of three exons and spans at least 5kb. Exons 1 and 2 encode for 5' untranslated mRNA sequence and exon 3 harbors the entire uninterrupted open reading frame. [provided by RefSeq]

Specifications

Antigen AGTR2
Applications Immunohistochemistry (PFA fixed)
Classification Polyclonal
Conjugate Unconjugated
Description Rabbit polyclonal antibody raised against synthetic peptide of AGTR2.
Dilution Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (10 ug/mL) The optimal working dilution should be determined by the end user.
Formulation In PBS (0.09% sodium azide)
Gene AGTR2
Gene Alias AT2/ATGR2/MRX88
Gene Symbols AGTR2
Host Species Rabbit
Immunogen A synthetic peptide corresponding to 16 amino acids at internal region of human AGTR2.
Purification Method Immunoaffinity chromatography
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 186
Test Specificity BLAST analysis of the peptide immunogen showed no homology with other human proteins, except GPR65 (63%), NPFFR2 (44%).
Target Species Bovine, Canine, Equine, Hamster, Human, Monkey, Mouse, Pig, Rat, Sheep
Content And Storage Store at 4°C. For long term storage store at -80°C.
Aliquot to avoid repeated freezing and thawing.
Form Liquid
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