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AKT1 (phospho T34), Rabbit, Polyclonal Antibody, Abnova™

Catalog No. 89133491 Shop All Abnova Corporation Products
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89-133-491 100 μL
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Catalog No. 89-133-491 Supplier Abnova Corporation Supplier No. PAB7912
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Description

Rabbit polyclonal antibody raised against synthetic phosphopeptide of AKT1.

The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq

Specifications

Antigen AKT1
Applications ELISA, Western Blot
Classification Polyclonal
Conjugate Unconjugated
Description Rabbit polyclonal antibody raised against synthetic phosphopeptide of AKT1.
Dilution ELISA (1:2000) Western Blot (1:500) The optimal working dilution should be determined by the end user.
Formulation In PBS (50% glycerol, 1mg/mL BSA, 0.05% sodium azide)
Gene AKT1
Gene Alias AKT/MGC99656/PKB/PKB-ALPHA/PRKBA/RAC/RAC-ALPHA
Gene Symbols AKT1
Host Species Rabbit
Immunogen Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding T34 of human AKT1.
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 207
Test Specificity This sequence is highly conserved in rat and mouse Akt.
Target Species Human, Rabbit, Rat
Content And Storage Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
Form Liquid
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For Research Use Only

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