AKT1 Rabbit anti-Human, Mouse, Rat, Polyclonal Antibody, Abnova™
Rabbit polyclonal antibody raised against synthetic peptide of AKT1.
Manufacturer: Abnova Corporation PAB18072
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq
|Rabbit polyclonal antibody raised against synthetic peptide of AKT1.|
|In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)|
|A synthetic peptide corresponding to residues surrounding S246 of human AKT1.|
|Human, Murine, Rat|
|ELISA, Immunohistochemistry, Immunohistochemistry (PFA fixed), Western Blot|
|Western Blot (1:500∼1:1000) Immunohistochemistry (1:50∼1:100) ELISA(1:5000) The optimal working dilution should be determined by the end user.|
|This antibody is specific to AKT1.|
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