ALK (phospho Y1096), Rabbit anti-Human, Mouse, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic phosphopeptide of human ALK.

Supplier:  Abnova Corporation PAB29294

Catalog No. 89-130-732

Description

The 2;5 chromosomal translocation is frequently associated with anaplastic large cell lymphomas (ALCLs). The translocation creates a fusion gene consisting of the ALK (anaplastic lymphoma kinase) gene and the nucleophosmin (NPM) gene: the 3' half of ALK, derived from chromosome 2, is fused to the 5' portion of NPM from chromosome 5. A recent study shows that the product of the NPM-ALK fusion gene is oncogenic. The deduced amino acid sequences reveal that ALK is a novel receptor protein-tyrosine kinase having a putative transmembrane domain and an extracellular domain. These sequences are absent in the product of the transforming NPM-ALK gene. ALK shows the greatest sequence similarity to LTK (leukocyte tyrosine kinase). ALK plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. [provided by RefSeq]

Specifications

• Antigen: ALK
• Classification: Polyclonal
• Description: Rabbit polyclonal antibody raised against synthetic phosphopeptide of human ALK.
• Formulation: In PBS (without mg²⁺ and Ca²⁺), 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
• Gene Accession No.: Q9UM73
• Gene Symbols: ALK
• Immunogen: Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding Y1096 of human ALK.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Test Specificity: ALK (phospho Y1096) polyclonal antibody detects endogenous levels of human ALK only when phosphorylated at tyrosine 1096.
• Content And Storage: Store at -20°C.
  Aliquot to avoid repeated freezing and thawing.

• Applications: Immunohistochemistry (PFA fixed)
• Conjugate: Unconjugated
• Dilution: Immunohistochemistry (1:50∼1:100) The optimal working dilution should be determined by the end user.
• Gene: ALK
• Gene Alias: CD246/Ki-1/TFG/ALK
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 238
• Target Species: Human, Mouse
• Form: Liquid

For Research Use Only