MilliporeSigma™ Rabbit anti-ALKBH1, Polyclonal,

Rabbit Polyclonal Antibody

Supplier:  MilliporeSigma™ ABE1310

Catalog No. ABE1310MI

Description

Specifically detects ALKBH1 in Human, Mouse samples, and it is validated for Immunocytochemistry, Immunohistochemistry

ALKBH1 is a DNA lyase that is critical for DNA repair and specifically repairs alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative demethylation. ALKBH1 can also cleave both single-stranded and double-stranded DNA at basic sites, and ALKBH1 can induce double stranded breaks at basic sites. Finally, ALKBH1 plays a role in placental trophoblast lineage differentiation during development, and ALKBH1 may also play a role in neuronal development and migration. ALKBH1 is widely expressed and localizes to mitochondria and nucleus. The nuclear localization of ALKBH1 appears to be as part of fusion proteins with nuclear targeted proteins or when the first 26 N-terminal residues are removed.

Specifications

• Antigen: ALKBH1
• Classification: Polyclonal
• Gene Accession No.: Q13686
• Host Species: Rabbit
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human, Mouse

• Applications: Immunocytochemistry, Immunohistochemistry
• Formulation: Purified rabbit polyclonal in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
• Gene Symbols: ALKBH1; ABH; ABH1; ALKBH
• Immunogen: KLH-conjugated linear peptide corresponding to the substrate binding region of human ALKBH1.
• Quantity: 100 μg
• Research Discipline: Epigenetics and Nuclear Function
• Gene ID (Entrez): NP_006011
• Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.

For Research Use Only