ALOX5 Rabbit anti-Bovine, Human, Mouse, Rabbit, Rat, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic peptide of ALOX5.

Supplier:  Abnova Corporation PAB12489

Catalog No. 89-115-863

Description

This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined. [provided by RefSeq

Specifications

• Antigen: ALOX5
• Classification: Polyclonal
• Description: Rabbit polyclonal antibody raised against synthetic peptide of ALOX5.
• Formulation: In PBS (30% glycerol, 0.09% sodium azide)
• Gene Accession No.: P09917
• Gene Symbols: ALOX5
• Immunogen: A synthetic peptide corresponding to amino acids 600-674 of human ALOX5.
• Regulatory Status: RUO
• Gene ID (Entrez): 240
• Content And Storage: Store at -20°C or -80°C.
  Aliquot to avoid repeated freezing and thawing.

• Applications: Western Blot
• Conjugate: Unconjugated
• Dilution: Western Blot (1:500-1:1000) The optimal working dilution should be determined by the end user.
• Gene: ALOX5
• Gene Alias: 5-LO/5-LOX/5LPG/LOG5/MGC163204
• Host Species: Rabbit
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Bovine, Human, Mouse, Rabbit, Rat
• Form: Liquid

For Research Use Only