ALPL Rabbit anti-Human, Mouse, Rat, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic peptide of ALPL.

Supplier:  Abnova Corporation PAB12279

Catalog No. 89-115-687

Description

There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue nonspecific). The first three are located together on chromosome 2, while the tissue nonspecific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq

Specifications

• Antigen: ALPL
• Classification: Polyclonal
• Description: Rabbit polyclonal antibody raised against synthetic peptide of ALPL.
• Formulation: Lyophilized from 0.9mg NaCl, 0.2mg Na₂HPO₄ (5mg BSA, 0.05mg sodium azide, 0.05mg Thimerosal)
• Gene Accession No.: AB011406
• Gene Symbols: ALPL
• Immunogen: A synthetic peptide corresponding to amino acids at N-terminus of human ALPL.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Test Specificity: Different from the related rat and mouse sequence by two amino acids.
• Content And Storage: Store at -20°C on dry atmosphere. After reconstitution with 200μL of deionized water and concentration will be 500μ/mL store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
• Isotype: IgG

• Applications: Immunohistochemistry (PFA fixed), Western Blot
• Conjugate: Unconjugated
• Dilution: Western Blot (1-2 ug/mL) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1-2 ug/mL) The optimal working dilution should be determined by the end user.
• Gene: ALPL
• Gene Alias: AP-TNAP/FLJ40094/FLJ93059/HOPS/MGC161443/MGC167935/TNAP/TNSALP
• Host Species: Rabbit
• Purification Method: Affinity purification
• Regulatory Status: RUO
• Gene ID (Entrez): 249
• Target Species: Human, Mouse, Rat
• Form: Lyophilized

For Research Use Only