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ANPEP, Rabbit, Clone: SP182, Abnova™

Catalog No. 89110300 Shop All Abnova Corporation Products
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89-110-300 100 μL
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Catalog No. 89-110-300 Supplier Abnova Corporation Supplier No. MAB12159

Description

Rabbit monoclonal antibody raised against synthetic peptide of human ANPEP.

Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma. [provided by RefSeq

Specifications

Antigen ANPEP
Applications Flow Cytometry, Immunohistochemistry (PFA fixed)
Classification Monoclonal
Clone SP182
Conjugate Unconjugated
Description Rabbit monoclonal antibody raised against synthetic peptide of human ANPEP.
Dilution Flow Cytometry (1:400) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:100) The optimal working dilution should be determined by the end user.
Formulation In 10mM PBS, pH 7.6 (1% BSA, 0.09% sodium azide)
Gene ANPEP
Gene Alias APN/CD13/LAP1/PEPN/gp150/p150
Gene Symbols ANPEP
Host Species Rabbit
Immunogen A synthetic peptide corresponding to internal region of human ANPEP.
Purification Method Protein A/G purification
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 290
Target Species Human
Content And Storage Store at 4°C.
Form Liquid
Isotype IgG
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