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APAF1 Rabbit anti-Human, Polyclonal Antibody, Abnova™

Catalog No. 89114912 Shop All Abnova Corporation Products
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Catalog No. Quantity
89-114-912 100 μL
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Catalog No. 89-114-912 Supplier Abnova Corporation Supplier No. PAB11191

Description

Rabbit polyclonal antibody raised against synthetic peptide of APAF1.

This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq

Specifications

Antigen APAF1
Applications Immunohistochemistry (PFA fixed)
Classification Polyclonal
Concentration Lot specific
Conjugate Unconjugated
Description Rabbit polyclonal antibody raised against synthetic peptide of APAF1.
Dilution Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (Formalin/PFA-fixed paraffin-embedded sections) (1:200) The optimal working dilution should be determined by the end user.
Formulation In 10mM PBS, pH 7.4 (1% BSA, 0.09% sodium azide)
Gene APAF1
Gene Alias CED4/DKFZp781B1145
Gene Symbols APAF1
Host Species Rabbit
Immunogen A synthetic peptide corresponding to C-terminus of human APAF1.
Purification Method Immunoaffinity purification
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 317
Target Species Human
Content And Storage Store at 4°C.
Form Liquid
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For Research Use Only

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