APAF1 Rabbit anti-Human, Polyclonal Antibody, Abnova™

Catalog No.	Quantity
89-126-466	100 μL

Catalog No. 89-126-466 Supplier Abnova Corporation Supplier No. PAB24797

Description

Rabbit polyclonal antibody raised against synthetic peptide of APAF1.

This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq

Specifications

• Antigen: APAF1
• Applications: Immunofluorescence, Immunohistochemistry (PFA fixed), Western Blot
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Description: Rabbit polyclonal antibody raised against synthetic peptide of APAF1.
• Dilution: Western Blot (1:500-1:1000) Immunohistochemistry (1:50-1:200) Immunofluorescence (1:50-1:200) The optimal working dilution should be determined by the end user.
• Formulation: In PBS, pH 7.2 (0.05% sodium azide)
• Gene: APAF1
• Gene Alias: CED4/DKFZp781B1145
• Gene Symbols: APAF1
• Host Species: Rabbit
• Immunogen: A synthetic peptide corresponding to APAF1.
• Purification Method: Antigen affinity purification
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 317
• Test Specificity: APAF1 polyclonal antibody detects endogenous levels of APAF1 protein.
• Target Species: Human
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid

For Research Use Only