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Description
This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq
Specifications
Specifications
| Antigen | APC |
| Applications | ELISA, Immunohistochemistry, Immunohistochemistry (PFA fixed) |
| Classification | Polyclonal |
| Conjugate | Unconjugated |
| Description | Rabbit polyclonal antibody raised against synthetic peptide of APC. |
| Dilution | Immunohistochemistry (1:50∼1:100) ELISA (1:40000) The optimal working dilution should be determined by the end user. |
| Formulation | In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide) |
| Gene | APC |
| Gene Accession No. | P25054 |
| Gene Alias | BTPS2/DP2/DP2.5/DP3/GS |
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